ML-SA1 is a chemical compound which acts as an \"agonist\" of the TRPML family of calcium channels. It has mainly been studied for its role in activating TRPML1 channels, although it also shows activity at the less studied TRPML2 and TRPML3 subtypes. TRPML1 is important for the function of lysosomes, and ML-SA1 has been used to study several disorders resulting from impaired lysosome function, including mucolipidosis type IV and Niemann-Pick's disease type C, as well as other conditions such as stroke and Alzheimer's disease.
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{"type":"standard","title":"Lipa Cathedral","displaytitle":"Lipa Cathedral","namespace":{"id":0,"text":""},"wikibase_item":"Q19895799","titles":{"canonical":"Lipa_Cathedral","normalized":"Lipa Cathedral","display":"Lipa Cathedral"},"pageid":44701368,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/e/e5/Lipa_Cathedral_2024-03-27.jpg/330px-Lipa_Cathedral_2024-03-27.jpg","width":320,"height":240},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/e/e5/Lipa_Cathedral_2024-03-27.jpg","width":4000,"height":3000},"lang":"en","dir":"ltr","revision":"1246037518","tid":"6ac61d4b-743c-11ef-9dd7-c966391252d2","timestamp":"2024-09-16T15:00:31Z","description":"Roman Catholic cathedral in Batangas, Philippines","description_source":"local","coordinates":{"lat":13.940951,"lon":121.163254},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Lipa_Cathedral","revisions":"https://en.wikipedia.org/wiki/Lipa_Cathedral?action=history","edit":"https://en.wikipedia.org/wiki/Lipa_Cathedral?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Lipa_Cathedral"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Lipa_Cathedral","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Lipa_Cathedral","edit":"https://en.m.wikipedia.org/wiki/Lipa_Cathedral?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Lipa_Cathedral"}},"extract":"The Metropolitan Cathedral of San Sebastian, commonly known as Lipa Cathedral, is a Neo-Renaissance cathedral in Lipa, Batangas, Philippines. The cathedral serves as the seat of the Archdiocese of Lipa. The cathedral was chosen as the seat of the then Diocese of the Lipa in 1910. Detached from the Archdiocese of Manila and canonically erected by Pope Pius X, it comprised what are today the provinces of Batangas, Quezon, Aurora, Laguna, Marinduque, Occidental Mindoro, Oriental Mindoro, and part of the Camarines area.","extract_html":"
The Metropolitan Cathedral of San Sebastian, commonly known as Lipa Cathedral, is a Neo-Renaissance cathedral in Lipa, Batangas, Philippines. The cathedral serves as the seat of the Archdiocese of Lipa. The cathedral was chosen as the seat of the then Diocese of the Lipa in 1910. Detached from the Archdiocese of Manila and canonically erected by Pope Pius X, it comprised what are today the provinces of Batangas, Quezon, Aurora, Laguna, Marinduque, Occidental Mindoro, Oriental Mindoro, and part of the Camarines area.
"}{"fact":"A commemorative tower was built in Scotland for a cat named Towser, who caught nearly 30,000 mice in her lifetime.","length":114}
{"type":"standard","title":"Rauschwitz","displaytitle":"Rauschwitz","namespace":{"id":0,"text":""},"wikibase_item":"Q565933","titles":{"canonical":"Rauschwitz","normalized":"Rauschwitz","display":"Rauschwitz"},"pageid":13661818,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/f/f4/Rauschwitz_in_SHK.svg/330px-Rauschwitz_in_SHK.svg.png","width":320,"height":281},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/f/f4/Rauschwitz_in_SHK.svg/1124px-Rauschwitz_in_SHK.svg.png","width":1124,"height":988},"lang":"en","dir":"ltr","revision":"1230911889","tid":"e99c2e9f-32e5-11ef-abb4-647ee687282b","timestamp":"2024-06-25T11:27:32Z","description":"Municipality in Thuringia, Germany","description_source":"local","coordinates":{"lat":50.97194444,"lon":11.80194444},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Rauschwitz","revisions":"https://en.wikipedia.org/wiki/Rauschwitz?action=history","edit":"https://en.wikipedia.org/wiki/Rauschwitz?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Rauschwitz"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Rauschw